American Cruise Line Cruises

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  • American Heritage
    4.8 rating out of 5  (7 reviews)

    6 Night Historic Mississippi River

    American Heritage

    Departing from: New Orleans, Louisiana
    Ports of Call:
    • Oak Alley Plantation, Vacherie, Louisiana
    • Baton Rouge, Louisiana
    • Natchez, Mississippi
    • St. Francisville, Louisiana
    Sailing Dates:
    • October 2025
    • November 2025
    • March 2026
    • April 2026
    • May 2026
    • June 2026
    • October 2026
    • November 2026
    • June 2027
    • November 2027
    • March 2028
    • April 2028
    • May 2028
    • October 2028
    • November 2028
    interior from
    Not Available
    oceanview from
    $3,320
    $553pernight
    balcony from
    $3,855
    $643pernight
    suite from
    $5,485
    $914pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $4,255 – Save up to 9%
    Riverview from $3,320
    ($553pernight)
    4.8 rating out of 5  (7 reviews)

American Cruise Lines

  • American Splendor
    4.3 rating out of 5  (6 reviews)

    7 Night Lower Mississippi River

    American Splendor

    Departing from: New Orleans, Louisiana
    Ports of Call:
    • Oak Alley Plantation, Vacherie, Louisiana
    • Houmas House Plantation, Louisiana
    • St. Francisville, Louisiana
    • Natchez, Mississippi
    • Vicksburg, Mississippi
    • Cleveland, Mississippi
    • Memphis, Tennessee
    Sailing Dates:
    • November 2025
    • February 2026
    • March 2026
    • April 2026
    • May 2026
    • June 2026
    • July 2026
    • August 2026
    • November 2026
    • February 2027
    • March 2027
    • April 2027
    • May 2027
    • June 2027
    • July 2027
    • November 2027
    • February 2028
    • March 2028
    • April 2028
    • May 2028
    • June 2028
    • July 2028
    • November 2028
    interior from
    Not Available
    oceanview from
    $3,795
    $542pernight
    balcony from
    $4,415
    $631pernight
    suite from
    $6,300
    $900pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $4,915 – Save up to 10%
    Riverview from $3,795
    ($542pernight)
    4.3 rating out of 5  (6 reviews)
  • American Splendor
    4.3 rating out of 5  (6 reviews)

    7 Night Music Cities

    American Splendor

    Departing from: Nashville, Tennessee
    Ports of Call:
    • Clarksville, Tennessee
    • Dover, Tennessee
    • River Cruising
    • Paducah, Kentucky
    • River Cruising
    • Memphis, Tennessee
    Sailing Dates:
    • September 2025
    • October 2025
    • June 2026
    • July 2026
    • August 2026
    • September 2026
    • October 2026
    • October 2027
    • October 2028
    interior from
    Not Available
    oceanview from
    $4,110
    $587pernight
    balcony from
    $4,775
    $682pernight
    suite from
    $6,795
    $971pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $5,275 – Save up to 9%
    Riverview from $4,110
    ($587pernight)
    4.3 rating out of 5  (6 reviews)
  • American Splendor
    4.3 rating out of 5  (6 reviews)

    7 Night Tennessee Rivers

    American Splendor

    Departing from: Chattanooga, Tennessee
    Ports of Call:
    • Decatur, Alabama
    • Florence, Alabama
    • Savannah, Tennessee
    • Paducah, Kentucky
    • River Cruising
    • Nashville, Tennessee
    Sailing Dates:
    • August 2026
    • September 2026
    • August 2027
    • September 2027
    • October 2027
    • August 2028
    • September 2028
    • October 2028
    interior from
    Not Available
    oceanview from
    $4,295
    $614pernight
    balcony from
    $4,915
    $702pernight
    suite from
    $6,800
    $971pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Riverview from $4,295
    ($614pernight)
    4.3 rating out of 5  (6 reviews)
  • American Splendor
    4.3 rating out of 5  (6 reviews)

    7 Night Tennessee Rivers

    American Splendor

    Departing from: Nashville, Tennessee
    Ports of Call:
    • Paducah, Kentucky
    • Savannah, Tennessee
    • Florence, Alabama
    • Decatur, Alabama
    • River Cruising
    • Chattanooga, Tennessee
    Sailing Dates:
    • July 2026
    • September 2026
    • July 2027
    • August 2027
    • September 2027
    • October 2027
    • July 2028
    • August 2028
    • September 2028
    • October 2028
    interior from
    Not Available
    oceanview from
    $4,295
    $614pernight
    balcony from
    $4,915
    $702pernight
    suite from
    $6,800
    $971pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Riverview from $4,295
    ($614pernight)
    4.3 rating out of 5  (6 reviews)
  • American Symphony
    3.5 rating out of 5  (5 reviews)

    7 Night Lower Mississippi River

    American Symphony

    Departing from: Memphis, Tennessee
    Ports of Call:
    • Cleveland, Mississippi
    • Vicksburg, Mississippi
    • Natchez, Mississippi
    • St. Francisville, Louisiana
    • River Cruising
    • Houmas House Plantation, Louisiana
    • New Orleans, Louisiana
    Sailing Dates:
    • November 2025
    • December 2025
    • January 2026
    • April 2026
    • July 2026
    • August 2026
    • November 2026
    • December 2026
    • February 2027
    • March 2027
    • April 2027
    • June 2027
    • November 2027
    • December 2027
    • June 2028
    • November 2028
    • December 2028
    interior from
    Not Available
    oceanview from
    Not Available
    balcony from
    $4,275
    $611pernight
    suite from
    $6,295
    $899pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $5,275 – Save up to 19%
    Balcony from $4,275
    ($611pernight)
    3.5 rating out of 5  (5 reviews)
  • American Symphony
    3.5 rating out of 5  (5 reviews)

    7 Night Lower Mississippi River

    American Symphony

    Departing from: New Orleans, Louisiana
    Ports of Call:
    • Oak Alley Plantation, Vacherie, Louisiana
    • Houmas House Plantation, Louisiana
    • St. Francisville, Louisiana
    • Natchez, Mississippi
    • Vicksburg, Mississippi
    • Cleveland, Mississippi
    • Memphis, Tennessee
    Sailing Dates:
    • November 2025
    • December 2025
    • April 2026
    • July 2026
    • September 2026
    • November 2026
    • December 2026
    • February 2027
    • March 2027
    • April 2027
    • November 2027
    • September 2028
    • November 2028
    • December 2028
    interior from
    Not Available
    oceanview from
    Not Available
    balcony from
    $4,525
    $646pernight
    suite from
    $6,545
    $935pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $5,275 – Save up to 14%
    Balcony from $4,525
    ($646pernight)
    3.5 rating out of 5  (5 reviews)
  • American Constellation
    4.9 rating out of 5  (7 reviews)

    7 Night Puget Sound & San Juan Islands

    American Constellation

    Departing from: Seattle, Washington
    Ports of Call:
    • Anacortes, Washington
    • Friday Harbor, San Juan Island, Washington
    • Cruise San Juan Islands
    • Victoria, British Columbia
    • Port Townsend, Washington
    • Poulsbo, Washington
    Sailing Dates:
    • September 2025
    • October 2025
    • March 2026
    • April 2026
    • May 2026
    • September 2026
    • October 2026
    • March 2028
    • April 2028
    • May 2028
    • September 2028
    • October 2028
    interior from
    Not Available
    oceanview from
    $4,675
    $668pernight
    balcony from
    $5,490
    $784pernight
    suite from
    $7,540
    $1,077pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $6,240 – Save up to 12%
    Riverview from $4,675
    ($668pernight)
    4.9 rating out of 5  (7 reviews)
  • American Constitution
    5 rating out of 5  (5 reviews)

    7 Night Puget Sound & San Juan Islands

    American Constitution

    Departing from: Seattle, Washington
    Ports of Call:
    • Anacortes, Washington
    • Friday Harbor, San Juan Island, Washington
    • Cruise San Juan Islands
    • Victoria, British Columbia
    • Port Townsend, Washington
    • Poulsbo, Washington
    Sailing Dates:
    • September 2025
    • October 2025
    • March 2026
    • April 2026
    • May 2026
    • September 2026
    • October 2026
    • September 2027
    • October 2027
    • March 2028
    • April 2028
    • May 2028
    • September 2028
    • October 2028
    interior from
    Not Available
    oceanview from
    $4,675
    $668pernight
    balcony from
    $5,490
    $784pernight
    suite from
    $7,540
    $1,077pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $6,240 – Save up to 12%
    Riverview from $4,675
    ($668pernight)
    5 rating out of 5  (5 reviews)
  • American Pride
    4.4 rating out of 5  (7 reviews)

    7 Night Columbia & Snake Rivers

    American Pride

    Departing from: Portland, Oregon
    Ports of Call:
    • Astoria, Oregon
    • Kalama, Washington
    • The Dalles, Oregon
    • Cruise Columbia River, Pacific Northwest, Usa
    • Pendleton, Oregon
    • Clarkston, Washington
    Sailing Dates:
    • September 2025
    • October 2025
    • November 2025
    • April 2026
    • May 2026
    • June 2026
    • July 2026
    • August 2026
    • September 2026
    • October 2026
    • April 2027
    • May 2027
    • June 2027
    • July 2027
    • August 2027
    • September 2027
    • October 2027
    • April 2028
    • May 2028
    • June 2028
    • July 2028
    • August 2028
    • September 2028
    • October 2028
    interior from
    Not Available
    oceanview from
    $5,240
    $749pernight
    balcony from
    $5,995
    $856pernight
    suite from
    $8,290
    $1,184pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Riverview from $5,240
    ($749pernight)
    4.4 rating out of 5  (7 reviews)
  • American Eagle
    5 rating out of 5  (3 reviews)

    7 Night Great Rivers of Florida

    American Eagle

    Departing from: Jacksonville, Florida
    Ports of Call:
    • Green Cove Springs, Florida
    • Palatka, Florida
    • Amelia Island, Florida
    • St. Augustine, Florida
    Sailing Dates:
    • November 2025
    • December 2025
    • January 2026
    • February 2026
    • March 2026
    • November 2026
    • December 2026
    • January 2027
    • February 2027
    • March 2027
    • May 2027
    • December 2027
    • May 2028
    • November 2028
    • December 2028
    interior from
    Not Available
    oceanview from
    $5,030
    $719pernight
    balcony from
    $5,975
    $854pernight
    suite from
    $8,155
    $1,165pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $6,575 – Save up to 9%
    Riverview from $5,030
    ($719pernight)
    5 rating out of 5  (3 reviews)
  • American Legend
    5 rating out of 5  (1 reviews)

    7 Night Florida Gulf Coast & Keys

    American Legend

    Departing from: St. Petersburg, Florida
    Ports of Call:
    • Marco Island, Florida
    • Key West, Florida
    • River Cruising
    • Punta Gorda, Florida
    Sailing Dates:
    • November 2025
    • December 2025
    • January 2026
    • February 2026
    • March 2026
    interior from
    Not Available
    oceanview from
    Not Available
    balcony from
    $5,575
    $796pernight
    suite from
    $7,755
    $1,108pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $6,575 – Save up to 15%
    Balcony from $5,575
    ($796pernight)
    5 rating out of 5  (1 reviews)
  • American Harmony
    5 rating out of 5  (6 reviews)

    7 Night Columbia & Snake Rivers

    American Harmony

    Departing from: Portland, Oregon
    Ports of Call:
    • Astoria, Oregon
    • Kalama, Washington
    • The Dalles, Oregon
    • Cruise Columbia River, Pacific Northwest, Usa
    • Pendleton, Oregon
    • Clarkston, Washington
    Sailing Dates:
    • September 2025
    • October 2025
    • March 2026
    • April 2026
    • May 2026
    • June 2026
    • July 2026
    • August 2026
    • September 2026
    • October 2026
    • November 2026
    • April 2027
    • May 2027
    • June 2027
    • July 2027
    • August 2027
    • September 2027
    • October 2027
    • April 2028
    • May 2028
    • June 2028
    • July 2028
    • August 2028
    • September 2028
    • October 2028
    interior from
    Not Available
    oceanview from
    Not Available
    balcony from
    $5,855
    $836pernight
    suite from
    $8,285
    $1,184pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $6,355 – Save up to 8%
    Balcony from $5,855
    ($836pernight)
    5 rating out of 5  (6 reviews)
  • American Constellation
    4.9 rating out of 5  (7 reviews)

    7 Night Southeast Alaska

    American Constellation

    Departing from: Juneau, Alaska
    Ports of Call:
    • Haines, Alaska
    • Glacier Bay National Park, Alaska (Scenic Cruising)
    • Petersburg, Alaska
    • Cruise Wrangell Narrows, Alaska
    • Wrangell, Alaska
    • Cruise Tracy Arm Fjord, Alaska
    Sailing Dates:
    • May 2026
    • June 2026
    • July 2026
    • August 2026
    • September 2026
    • June 2027
    • July 2027
    • August 2027
    • May 2028
    • June 2028
    • July 2028
    • August 2028
    • September 2028
    interior from
    Not Available
    oceanview from
    $6,225
    $889pernight
    balcony from
    $7,240
    $1,034pernight
    suite from
    $9,780
    $1,397pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $7,740 – Save up to 6%
    Riverview from $6,225
    ($889pernight)
    4.9 rating out of 5  (7 reviews)
  • American Constellation
    4.9 rating out of 5  (7 reviews)

    10 Night Alaskan Explorer

    American Constellation

    Departing from: Juneau, Alaska
    Ports of Call:
    • Haines, Alaska
    • Cruise Inside Passage, Alaska
    • Glacier Bay National Park, Alaska (Scenic Cruising)
    • Sitka, Alaska
    • Wrangell, Alaska
    • Cruise Wrangell Narrows, Alaska
    • Petersburg, Alaska
    • Cruise Inside Passage, Alaska
    • Cruise Tracy Arm Fjord, Alaska
    Sailing Dates:
    • June 2026
    • July 2026
    • August 2026
    • July 2027
    • August 2027
    • July 2028
    interior from
    Not Available
    oceanview from
    $8,525
    $853pernight
    balcony from
    $9,915
    $992pernight
    suite from
    $13,350
    $1,335pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $10,665 – Save up to 7%
    Riverview from $8,525
    ($853pernight)
    4.9 rating out of 5  (7 reviews)
  • American Constellation
    4.9 rating out of 5  (7 reviews)

    14 Night Alaska Inside Passage

    American Constellation

    Departing from: Seattle, Washington
    Ports of Call:
    • Anacortes, Washington
    • Friday Harbor, San Juan Island, Washington
    • Cruise Queen Charlotte Sound, British Columbia
    • Cruise Inside Passage, Alaska
    • Ketchikan, Alaska
    • Wrangell, Alaska
    • Petersburg, Alaska
    • Cruise Tracy Arm Fjord, Alaska
    • Cruise Glacier Bay National Park
    • Haines, Alaska
    • Skagway, Alaska
    • Juneau, Alaska
    Sailing Dates:
    • May 2026
    • May 2028
    interior from
    Not Available
    oceanview from
    $9,200
    $657pernight
    balcony from
    $10,730
    $766pernight
    suite from
    $14,455
    $1,033pernight
    Rewards & Bonus Offers:
    • Cruises.com Rewards: Earn 10 points per $1 and redeem for cash!
    • Complimentary Dining, Cocktail Parties and More
     
    Was $11,730 – Save up to 9%
    Riverview from $9,200
    ($657pernight)
    4.9 rating out of 5  (7 reviews)

American Cruise Line River Cruises

Enjoy exceptional value when you book discount American Cruise Line River cruises and discount river cruises with Cruises.com. Act now for the best deals on American Cruise Line river cruises and sail away with bonus offers that include free onboard spending, free cabin upgrades and more. Plus, discount American Cruise Line River cruises include all meals, accommodations, and countless onboard activities. Plan your river cruise vacation before these American Cruise Line deals are gone.

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